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Researchers from Princeton University's Department of Molecular Biology have identified a small RNA molecule that helps maintain the activity of stem cells Rnai and breast cancer both healthy and cancerous breast tissue.

Above, the microscopic image shows different cell types in the normal mammary ducts of a Rnai and breast cancer. The luminal cells red are milk-producing cells and the basal cells green have contractile functions, but also are responsible for regenerating the mammary gland, as they contain the majority of mammary gland stem cells. These stem cells, located in the outer layer of the gland, are exposed to microenvironmental factors and interact with various immune cells, including macrophages, in the mammary gland.

The study, which will be published in Rnai and breast cancer June issue of Nature Cell Biology, suggests that this "microRNA" promotes particularly deadly forms of breast cancer and that inhibiting the effects of Rnai and breast cancer molecule could improve the efficacy of existing breast cancer therapies.

Amateur and photograph and nude cells give rise to the different cell types in adult tissues but, in order to maintain these tissues throughout adulthood, stem cells must retain their activity for decades. Many tumors also contain so-called "cancer stem Rnai and breast cancer that can drive tumor formation.

Some tumors, such as triple-negative breast cancers, are particularly deadly because they contain large numbers of cancer stem cells that self-renew and resist differentiation. Conversely, when they increased LCOR levels, they could curtail mammary gland stem cell activity.

Kang and colleagues found that miRa was also expressed in human and mouse breast cancer stem cells. Just as boosting miRa levels helped normal mammary gland stem cells retain their activity, the researchers showed that miRa enhanced the ability of cancer stem cells to form tumors.

By increasing LCOR levels, in contrast, they could reduce the tumor-forming capacity of the cancer stem cells. In collaboration Rnai and breast cancer researchers led by Zhi-Ming Shao, a professor at Fudan University Shanghai Cancer Center in China, Kang's team found that breast cancer patients whose tumors expressed large amounts of miRa showed poor survival rates, whereas tumors with high levels of LCOR had a better prognosis.

Kang and colleagues found that LCOR sensitizes Young young flaccid cocks to the effects of interferon-signaling molecules released from Rnai and breast cancer and immune cells, particularly macrophages, in the mammary gland. During normal mammary gland development, these cells secrete interferon-alpha to promote cell differentiation and inhibit cell division, the researchers discovered.

The microRNA plays a similar role during tumorigenesis, protecting breast cancer stem cells from the effects of interferons secreted by immune cells present in the tumor. This work was supported by a Susan G. May 22, p. Immune cell provides cradle for mammary stem cells Read more.

Diabolical duo: Known breast cancer gene needs a partner to initiate and spread tumors Read more. Small bits of genetic material fight cancer's spread Read more. Princeton scientists discover an interaction that helps cancers spread to bone Read more. Scientists discover mechanism involved in breast cancer's Rnai and breast cancer to bone Read more.

Cancer collaboration could someday help dogs and their humans Read more. Kang works to pinpoint cause of cancer spread Read more.


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